Research Directions
Exploring single-cell metabolomics, AI-driven drug efficacy predictions, and mechanisms of aging-related diseases.
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publications
Multiplatform metabolomics reveals novel serum metabolite biomarkers in diabetic retinopathy subjects
Published in Advanced Science, 2020
Recommended citation: Advanced Science 7 (22), 2001714, 2020
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Parallel derivatization strategy coupled with liquid chromatography-mass spectrometry for broad coverage of steroid hormones
Published in Journal of Chromatography a, 2020
Recommended citation: Journal of Chromatography a 1614, 460709, 2020
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Single-cell metabolomics analysis by microfluidics and mass spectrometry: recent new advances
Published in Springer Singapore, 2020
Recommended citation: Journal of Analysis and Testing 4 (3), 198-209, 2020
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Synthesis of metal-organic framework-5@ chitosan material for the analysis of microcystins and nodularin based on ultra-performance liquid chromatography-tandem mass spectrometry
Published in Journal of Chromatography A, 2020
Recommended citation: Journal of Chromatography A 1623, 461198, 2020
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Lipid profiling of 20 mammalian cells by capillary microsampling combined with high-resolution spectral stitching nanoelectrospray ionization direct-infusion mass spectrometry
Published in Analytical chemistry, 2021
Recommended citation: Analytical chemistry 93 (29), 10031-10038, 2021
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Metabolome‐genome‐wide association study (mGWAS) reveals novel metabolites associated with future type 2 diabetes risk and susceptibility loci in a case‐control study in a Chinese prospective cohort
Published in Global Challenges, 2021
Recommended citation: Global Challenges 5 (4), 2000088, 2021
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High-throughput single cell metabolomics and cellular heterogeneity exploration by inertial microfluidics coupled with pulsed electric field-induced electrospray ionization-high resolution mass spectrometry
Published in Analytica Chimica Acta, 2022
Recommended citation: Analytica Chimica Acta 1221, 340116, 2022
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In-depth characterization of nitrogen heterocycles of petroleum by liquid chromatography-energy-resolved high resolution tandem mass spectrometry
Published in Talanta, 2022
Recommended citation: Talanta 249, 123654, 2022
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Recent advances and typical applications in mass spectrometry-based technologies for single-cell metabolite analysis
Published in Elsevier, 2022
Recommended citation: TrAC Trends in Analytical Chemistry 157, 116763, 2022
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Steroid profiling for the diagnosis of congenital adrenal hyperplasia by microbore ultra-performance liquid chromatography–tandem mass spectrometry
Published in Clinica Chimica Acta, 2023
Recommended citation: Clinica Chimica Acta 543, 117304, 2023
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Concentric hybrid nanoelectrospray ionization‐atmospheric pressure chemical ionization source for high‐coverage mass spectrometry analysis of single‐cell metabolomics
Published in Advanced Science, 2024
Recommended citation: Advanced Science 11 (16), 2306659, 2024
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Polarization of macrophages in tumor microenvironment using high-throughput single-cell metabolomics
Published in Analytical Chemistry, 2024
Recommended citation: Analytical Chemistry 96 (37), 14935-14943, 2024
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Advances in KEAP1-based PROTACs as emerging therapeutic modalities: Structural basis and progress
Published in Elsevier, 2025
Recommended citation: Redox Biology, 103781, 2025
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Hepatic injury and metabolic perturbations in mice exposed to perfluorodecanoic acid revealed by metabolomics and lipidomics
Published in Ecotoxicology and Environmental Safety, 2025
Recommended citation: Ecotoxicology and Environmental Safety 289, 117475, 2025
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Therapeutic Effects of Sulforaphane on Helicobacter pylori-Infected Mice: Insights from High-Coverage Metabolomics and Lipidomics Analyses of Serum and Liver
Published in International Journal of Molecular Sciences, 2025
Recommended citation: International Journal of Molecular Sciences 26 (16), 7791, 2025
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DeepHeal: Consensus Variational Autoencoder Atlases of Drug-Induced Proteomic Perturbations Enable Phenotype-Based Drug Discovery and Mechanism-of-Action Analysis
Published in , 2026
Proteomic Perturbation Phenotype-Driven Reclassification of Anti-Tumor Drugs and Mechanistic Annotation of Natural Products
Published in , 2026
talks
teaching
无机化学实验
Undergraduate course, 福建中医药大学药学院，2025级药学3、4班, 2025
无机化学
Undergraduate course, 福建中医药大学药学院，2025级药学3、4班, 2025
有机化学
Undergraduate course, 福建中医药大学药学院，2024级食品科学与技术班, 2025
有机化学实验
Undergraduate course, 福建中医药大学药学院，2024级食品科学与技术班, 2025